HORDB

ID: hor005332
Uniprot ID: P28374
Protein name: Natriuretic peptide DNP
Gene name: NA
Organism: Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Family: Natriuretic peptide family
Source: Animal
Expression: Expressed by the venom gland.
Disease: NA
Comments: NA
Taxonomy: Dendroaspis (genus), Elapinae (subfamily), Elapidae (family), Colubroidea (superfamily), Serpentes (infraorder), Toxicofera, Episquamata, Unidentata, Bifurcata, Squamata (order), Lepidosauria (class), Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0015459 potassium channel regulator activity; GO:0090729 toxin activity; GO:0099106 ion channel regulator activity
GO BP: GO:0007165 signal transduction; GO:0008217 regulation of blood pressure; GO:0035821 modulation of process of another organism; GO:0042311 vasodilation; GO:0097746 blood vessel diameter maintenance
GO CC: GO:0005576 extracellular region

Function: Acts by stimulating cGMP via the natriuretic peptide receptor A (NPR1). Is a poor agonist of the atrial natriuretic peptide receptor B (NPR2).. Binds to atrial natriuretic peptide clearance receptor (NPR-C/NPR3), which may be responsible of the removal of
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: Artery log:7.94e(-7)mol;vein log :2.0e(-6)mol
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P28374-F1.pdb

hor005332_AF2.pdb

hor005332_ESM.pdb

Mass:	485283	Formula:	C180H284N56O56S2
Absent amino acids:	MQW	Common amino acids:	P
pI:	8.24	Basic residues:	7
Polar residues:	13	Hydrophobic residues:	9
Hydrophobicity:	-78.42	Boman Index:	-9558
Half-Life / Aliphatic Index:	1 hour	Aliphatic Index:	61.58
Instability Index:	4366.58	Extinction Coefficient cystines:	1615
Absorbance 280nm:	43.65